A decline in glycolytic ATP production is the fundamental mechanism limiting lifespan; species with an optimal rate of decline over time survived

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This pattern has caused connection pool exhaustion in Node.js applications using undici (the fetch() implementation built into Node.js), and similar issues have appeared in other runtimes. The stream holds a reference to the underlying connection, and without explicit consumption or cancellation, the connection may linger until garbage collection — which may not happen soon enough under load.

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