这项研究揭示了自闭症谱系障碍（ASD）的新机制：在丙戊酸（VPA）诱导的ASD小鼠模型中，大脑皮层出现了全局蛋白质合成过度增强。整合分析发现，这种异常并非源于转录水平，而是表现为核糖体和线粒体相关基因在翻译和蛋白水平的显著上调。进一步研究证实，翻译起始因子eIF4E的过度激活是导致上述翻译组异常及线粒体功能障碍的关键原因。重要的是，在幼年时期使用药物抑制eIF4E磷酸化，能持续缓解小鼠成年后的ASD样社交缺陷和刻板行为。
Nvidia's DLSS 4.5 with 6x Multi Frame Generation will be available starting March 31st for users with RTX 50-series GPUs, the company announced on Tuesday. With 6x Multi Frame Generation, Nvidia claims that DLSS 4.5 can generate "five additional frames for every single natively rendered one, for a maximum 6X multiplier." It's an increase from the maximum of three additional frames possible with DLSS 4.
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Nscale announced an "expanded partnership" with Microsoft in October, netting the younger company $14 billion, a figure first reported by the FT and verified by CNBC. Over the summer, it partnered with OpenAI to launch a Stargate-branded AI data center in Norway.