First atlas of brain organization shows development over a lifetime

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The passage of the sun across the sky — dawn, day, dusk, night — drives the clock of life. Some species wake with the sun and sleep with the moon. Others do the opposite, and a few keep odd hours. These naturally driven, 24-hour biological cycles are known as circadian rhythms, and they do more than cue bedtime: They regulate hormones, metabolism, DNA repair, and more. When life falls out of sync, there can be dire consequences for health, reproduction, and survival.

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更深入地研究表明,A paradigm can take hold even if incomplete, provided its core idea is sufficiently useful. For instance, Charles Darwin’s theory of natural selection offered a single principle that could explain the diversity of living species even though it still lacked an explanation for how traits actually passed from parent to offspring. In the late 1860s, he posited the missing mechanism, the erroneous notion of “pangenesis.” In it, he speculated that every cell in the body sheds tiny particles called “gemmules” that collect in the reproductive organs and transmit traits to offspring. Despite this error, Darwin’s core vision survived, and spread amongst biologists, before genetics supplied the necessary, physical mechanisms.

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