In 1996, David Deamer and Daniel Branton’s labs at UC Santa Cruz and Harvard collaborated on a paper showing that when an electric current runs through a nanopore, passing purine (A and G) and pyrimidine (T and C) DNA bases through the nanopore disrupted the current to different degrees. While the technique couldn’t yet discriminate between all four bases, the general idea for a new single-molecule sequencing method was there.
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小微商户是市场经济的“毛细血管”。丽水人在全国开办的超市有6万多家，可分散在各地的“丽水商超”普遍面临一些融资问题：经营商品流动性强、经营场地多为租赁，缺乏有效抵押物；再加上融资需求信息不对称，导致银行想贷难放贷。
Photograph: Brad Bourque